The World Health Organization (WHO) has released the second edition of its consolidated guidelines on TPT. The 21 recommendations contained in the second edition of the guidelines cover critical steps in programmatic management of TPT. The main changes from the first edition of the guidelines include a new, strong recommendation on TPT for contacts of multidrug- or rifampicin-resistant TB (MDR/RR-TB); the integration of recommendations from the 2021 WHO TB screening guidelines and the 2022 WHO guidelines on testing of TB infection; withdrawal of two older recommendations that presented issues to implementation; revisions to the wording of recommendations to align with current terminology; and updates to the research gaps and references.
